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The DDMoRe Project

Mango Solutions is proud to have been working as part of the Drug Disease Model Resources (DDMoRe) Consortium since March 2011.  The Consortium, supported by the Innovative Medicines Initiative (IMI), consists of 27 partners including members of EFPIA, Academia and SMEs. The project has been created to improve the quality, efficiency and cost effectiveness of Model-Informed Drug Discovery & Development.

Model-Informed Drug Discovery & Development (MID3) is accepted as a vital approach in understanding patient risk/benefit and attrition.  At the core of MID3 lies Modelling and Simulation (M&S), a technology providing the basis for informed, quantitative decision-making.  M&S facilitates the continuous integration of available information related to a drug or disease into constantly-evolving mathematical models capable of describing and predicting the behaviour of studied systems to address the questions researchers, regulators, and public health care bodies face when bringing drugs to patients.

However, full adoption of MID3 is frustrated by a lack of common tools, languages and ontologies for M&S, which often leads to inefficient reuse of data and duplication of effort by academic, industrial and regulatory stakeholders.

The scientific objectives of the project are to:

  1.      Enable efficient exchange and integration of modelling activities and outputs across software tools, disciplines and departments within and among organizations;
  2.     Provide standards applicable to all areas of M&S – ranging from PK/PD to pharmacometrics, and statistical analyses to systems biology, appropriate for use by all relevant domain stakeholders;
  3.     Develop an open, publicly available, free-to-use modelling library to promote the re-use of models, and to provide support for education and training in modelling & simulation;

 

The Drug Disease Model Resources (DDMoRe) consortium’s strategy it built upon the development of a new set of standards: a human readable language designed to describe pharmacometric models (Model Description Language – MDL), a common markup language for data, models and workflows (Pharmacometric Markup Language – PharmML), along with an ontology based standard for storage and transfer of models and associated metadata.

The DDMoRe Interoperability Framework supports the development of models in MDL by combining a sophisticated model development environment, a converter toolbox that translates models into many common programming tools and languages currently used by researchers performing M&S, and a task execution service that integrates with common grid technologies.

Mango’s involvement within the Consortium covers the specification and development of a number of the software components, including the PharmML to NM-TRAN language converter (allowing seamless integration of NONMEM), an R package to manipulate objects defined in the MDL, a workflow tool for recording the lifecycle and steps of model development, and the framework that permits integration with execution environments. We also assist with the development of the IDE, and maintain the environments that generate executable instances of the framework.

We are looking at integrating these components into the Navigator Workbench thus supporting the full lifecycle of model development, from data preparation and model selection, through to reporting

  • Navigator – our model development and reporting environment
    • Execution of models developed in MDL, integration of workflow tracking, support for the standard output object
  • ModSpace, our configurable model repository.
    • Store and parse models developed in MDL or PharmML, and support the metadata standards. ModSpace also allows you to store corresponding project documentation, data preparation and evaluation steps (e.g. with R) and the full history of the model’s development.   Click here to read more about how ModSpace makes it easy to start incorporating DDMoRe models and tools into your projects.

A Beta Version of the Interoperability Framework is now available for download.  Find out more here

If you’re interested in knowing more about the project, watch this video on the DDMoRe vision.

Click here to read more about how ModSpace makes it easy to start incorporating DDMoRe models and tools into your projects.